Association of sympathomimetic drugs with malformations
by Gilbert-Barness E, Drut RM Department of Pathology and Laboratory Medicine, University of South Florida, Tampa 33601, USA. Vet Hum Toxicol 2000 Jun; 42(3):168-71
We observed 2 cases of severe limb defects in infants following the use of sympathomimetic drugs during pregnancy. The mother of I had taken large doses of Primatene (ephedrine, theophylline, phenobarbital) as tablets and mist throughout pregnancy. The infant was born with oligoectrosyndactyly. In the other infant, maternal ingestion of sympathomimetic drugs including Triaminic (pseudoephedrine, phenylephrine, phenylpropanolamine) was associated with distal limb defects. Experimental studies in pregnant rabbits using Primatene in both low and high dosage resulted in limb reduction defects and other malformations in a significant number of the offspring compared with controls. Limb defects in the offspring of chicks following exposure to sympathomimetic drugs had previously been observed. We suggest that these agents may be teratogenic in the human and should be used with great caution or avoided during pregnancy.
For those seeking addiction treatment for themselves or a loved one, the Amphetamines.com helpline is a private and convenient solution.
Calls to any general helpline (non-facility specific 1-8XX numbers) for your visit will be answered by American Addiction Centers (AAC), a paid advertiser on Amphetamines.com.
AAC representatives are standing by 24/7 to discuss your treatment options. These representatives work solely for AAC and will discuss whether an AAC facility may be an option for you. This helpline is offered at no cost to you and with no obligation to enter into treatment. Neither Amphetamines.com nor AAC receives any commission or other fee that is dependent upon which treatment provider a visitor may ultimately choose.
For more information on AAC’s commitment to ethical marketing and treatment practices, or to learn more about how to select a treatment provider, visit AmericanAddictionCenters.org. If you wish to explore additional treatment options or connect with a specific rehab center, you can browse top-rated listings or visit SAMHSA.